Faculty Research Interests:
My research program is focused on understanding and utilizing the chemistry of nucleic acids. DNA plays an integral role in basic bioprocesses and its chemical and physical properties can be exploited to develop selective therapeutics, biosensors and even robust catalysts. I am looking for energetic and hard working students who want to delve into the science of DNA.
Recent Publications:
- Brown, T.; Taherbhai, Z.; Sexton, J.; Sutterfield, A.; Turlington, M.; Jones, J.; Stallings, L.; Stewart, M.; Buchmueller, K.; Mackay, H.; O'Hare, C.; Kluza, J.; Nguyen, B.; Wilson, D.; Lee, M.; Hartley, J.A. "Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin", Bioorganic & Medical Chemistry, 2007, 15, 474-83.
- Buchmueller, K.L.; Bailey, S.L.; Matthews, D.A.; Taherbhai, Z.T.; Register, J.K.; Davis, Z.S.; Bruce, C.D.; O'Hare, C.; Hartley, J.A.; Lee, M. "Physical and structural basis for the strong interactions of the -ImPy- central pairing motif in the polyamide f-ImPyIm", Biochemistry, 2006, 45, 13551-65.
- Flores, L.V.; Staples, A.M.; Mackay, H.; Howard, C.M.; Uthe, P.B.; Sexton, J.S., 3rd; Buchmueller, K.L.; Wilson, W.D.; O'Hare, C.; Kluza, J.; Hochhauser, D.; Hartley, J.A.; Lee, M. "Synthesis and evaluation of an intercalator-polyamide hairpin designed to target the inverted CCAAT box 2 in the topoisomerase IIalpha promoter", ChemBioChem, 2006, 7, 1722-9.
- Buchmueller, K. L.; Taherbhai, Z.; Howard, C. M.; Bailey, S. L.; Nguyen, B.; O'Hare, C.; Hochhauser, D.; Hartley, J. A.; Wilson, W. D.; Lee, M. "Design of a Hairpin Polyamide, ZT65B, for Targeting the Inverted CCAAT Box (ICB) Site in the Multidrug Resistant (MDR1) Gene ", ChemBioChem, 2005, 6, 2305-2311.
